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            <![CDATA[Welcome to Perspectives, a signature podcast series from the Leerink Center for Pharmacoeconomics. Hosted by Dr. Mel Whittington, a health economist and Head of the Center for Pharmacoeconomics, we will be hearing from individuals across the industry to better understand and appreciate the societal impact of healthcare innovations.]]>
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                    <copyright>© 2026 Perspectives by the Leerink Center for Pharmacoeconomics The Leerink Center for Pharmacoeconomics</copyright>
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        <pubDate>Sat, 25 Apr 2026 11:42:09 +0000</pubDate>
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            <title>What’s Behind Drug Pricing: The Hidden Role and Limits of Cost-Effectiveness Analysis</title>
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            <itunes:title>What’s Behind Drug Pricing: The Hidden Role and Limits of Cost-Effectiveness Analysis</itunes:title>
            <itunes:subtitle>In this episode of Perspectives by the Leerink Center for Pharmacoeconomics, Melanie Whittington breaks down a fundamental—and increasingly consequential—question in health economics: what counts a...</itunes:subtitle>
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                <![CDATA[In this episode of Perspectives by the Leerink Center for Pharmacoeconomics, Melanie Whittington breaks down a fundamental—and increasingly consequential—question in health economics: what counts as value in cost-effectiveness analysis?
 
For biotech leaders and investors, Mel cautions that this isn’t just an academic debate. The frameworks adopted by HTA bodies influence pricing, access, and ultimately, how innovation is rewarded.]]>
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            <pubDate>Tue, 31 Mar 2026 17:30:00 +0000</pubDate>
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            <title>Making Value Propositions Clearer with Peter Kolchinsky, PhD, Founder and Managing Partner, RA Capital Management</title>
            <itunes:episode>15</itunes:episode>

            
            <itunes:title>Making Value Propositions Clearer with Peter Kolchinsky, PhD, Founder and Managing Partner, RA Capital Management</itunes:title>
            <itunes:subtitle>Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, talks with Peter Kolchinsky, PhD, Founder and Managing Partner of RA Capital Management, to discuss if the U.S. market-ba...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, talks with Peter Kolchinsky, PhD, Founder and Managing Partner of RA Capital Management, to discuss if the U.S. market-based approach to pricing novel prescription medicines could result in paying more than they are worth and if companies and company builders should use health economic modeling to support their value propositions.]]>
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            <pubDate>Mon, 02 Mar 2026 18:00:00 +0000</pubDate>
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            <title>Specialty Drug Coverage Predictions with James Chambers, PhD, MPharm, Professor of Medicine, CEVR, Tufts Medical Center</title>
            <itunes:episode>14</itunes:episode>

            
            <itunes:title>Specialty Drug Coverage Predictions with James Chambers, PhD, MPharm, Professor of Medicine, CEVR, Tufts Medical Center</itunes:title>
            <itunes:subtitle>Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, interviews James Chambers, PhD, MPharm, Professor of Medicine in the Center for the Evaluation of Value and Risk in Healt...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, interviews James Chambers, PhD, MPharm, Professor of Medicine in the Center for the Evaluation of Value and Risk in Health at Tufts Medical Center, to dig into specialty drug coverage and what it might look like in 2026.]]>
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            <pubDate>Mon, 02 Feb 2026 18:30:00 +0000</pubDate>
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            <title>The National Pharmaceutical Council President and CEO &amp; Former Trump Drug Pricing Advisor, John O&#039;Brien, PharmD, MPH</title>
            <itunes:episode>13</itunes:episode>

            
            <itunes:title>The National Pharmaceutical Council President and CEO &amp; Former Trump Drug Pricing Advisor, John O&#039;Brien, PharmD, MPH</itunes:title>
            <itunes:subtitle>Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, talks with John M. O&#039;Brien, PharmD, MPH, President and CEO of the National Pharmaceutical Council &amp; Former Trump Drug Pri...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, talks with John M. O'Brien, PharmD, MPH, President and CEO of the National Pharmaceutical Council & Former Trump Drug Pricing Advisor, to tackle some big questions like if it is possible to reward innovation without busting budgets and how to get to a sustainable, innovation-friendly, patient-centered drug pricing system.  Additional resources:  

Subscribe to NPC’s Newsletter
https://www.npcnow.org/subscribe-updates 

IRA Impact on Pharmaceutical Investment: Insights From Investor Interviews (Health Affairs Scholar) 
https://academic.oup.com/healthaffairsscholar/article/3/9/qxaf156/8223954 

How Time Is Accounted For When Modeling Pharmaceutical Impacts: Investment vs Assessment Perspectives (Health Affairs Scholar)
https://academic.oup.com/healthaffairsscholar/article/3/9/qxaf169/8244606 

The IRA and Drug Development: Potential Early Signals of Impact on Post-Approval Clinical Trials (Therapeutic Innovation & Regulatory Science)
https://link.springer.com/article/10.1007/s43441-025-00774-2 

Subsequent Indications in Oncology Drugs: Pathways, Timelines, and the Inflation Reduction Act (Therapeutic Innovation & Regulatory Science) 
https://link.springer.com/article/10.1007/s43441-024-00706-6

Unintended Consequences of the Inflation Reduction Act: Clinical Development Toward Subsequent Indications (American Journal of Managed Care)
https://www.ajmc.com/view/unintended-consequences-of-the-inflation-reduction-act-clinical-development-toward-subsequent-indications

The Impact of the Inflation Reduction Act’s Drug Price Negotiation Program on Incentives for Clinical Development of New Drugs (Value in Health)
https://www.valueinhealthjournal.com/article/S1098-3015(25)02527-6/fulltext?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1098301525025276%3Fshowall%3Dtrue 

Follow John O’Brien on LinkedIn 
https://www.linkedin.com/in/drjmob/]]>
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            <pubDate>Thu, 08 Jan 2026 22:10:00 +0000</pubDate>
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            <title>David Hong, MD, Steve Potts, PhD, MBA, and Vivek Subbiah, MD talk Pan-Tumor Approvals in a Post-IRA World</title>
            <itunes:episode>12</itunes:episode>

            
            <itunes:title>David Hong, MD, Steve Potts, PhD, MBA, and Vivek Subbiah, MD talk Pan-Tumor Approvals in a Post-IRA World</itunes:title>
            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, talks with Vivek Subbiah, MD, David Hong, MD, and Steve Potts, PhD, MBA to discuss if pan-tumor approval strategies offer a pa...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, talks with Vivek Subbiah, MD, David Hong, MD, and Steve Potts, PhD, MBA to discuss if pan-tumor approval strategies offer a path forward for broader, faster adoption across larger patient populations. Given the slow adoption curves typical of new therapeutics and the potential for government price negotiation as early as nine years after market entry, the experts hash out if pan-tumor approval is a potential development and commercialization pathway to ramp up clinical adoption and sales early on. They discuss the challenges, data requirements, and opportunities of this relatively new development path. Dr. Hong is the Deputy Chair of the Department of Investigational Cancer Therapeutics at MD Anderson Cancer Center. Dr. Steve Potts is the CEO and Co-Founder of a Stealth Cancer Biotech. Dr. Subbiah is the Chief of Early Phase Drug Development at the Sarah Cannon Research Institute. All bring firsthand experience – wins and battle scars - with pan-tumor approvals.]]>
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            <pubDate>Tue, 02 Dec 2025 19:00:00 +0000</pubDate>
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            <title>Head of the Leerink Center for Pharmacoeconomics, Melanie Whittington, PhD</title>
            <itunes:episode>12</itunes:episode>

            
            <itunes:title>Head of the Leerink Center for Pharmacoeconomics, Melanie Whittington, PhD</itunes:title>
            <itunes:subtitle>Diane Vieira, Head of Marketing &amp; Communications at Leerink Partners, interviews Melanie Whittington, PhD, Head of the Leerink Center of Pharmacoeconomics (CPE), to discuss the one-year anniversary...</itunes:subtitle>
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                <![CDATA[Diane Vieira, Head of Marketing & Communications at Leerink Partners, interviews Melanie Whittington, PhD, Head of the Leerink Center of Pharmacoeconomics (CPE), to discuss the one-year anniversary of CPE and everything they thought they knew but actually didn’t.]]>
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            <pubDate>Mon, 03 Nov 2025 19:00:00 +0000</pubDate>
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            <title>Steve Potts, PhD, MBA, CEO and Co-Founder, Stealth Cancer Biotech</title>
            <itunes:episode>10</itunes:episode>

            
            <itunes:title>Steve Potts, PhD, MBA, CEO and Co-Founder, Stealth Cancer Biotech</itunes:title>
            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, interviews Steve Potts, PhD, MBA, CEO and Co-Founder, Stealth Cancer Biotech, to discuss the impact of the Inflation Reduction...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, interviews Steve Potts, PhD, MBA, CEO and Co-Founder, Stealth Cancer Biotech, to discuss the impact of the Inflation Reduction Act on cancer drug development and a middle ground between a market-based approach and a government-based approach to drug pricing.]]>
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            <pubDate>Mon, 06 Oct 2025 18:00:00 +0000</pubDate>
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            <title>The IP Policy Institute’s Joshua Kresh and Emily Michiko Morris</title>
            <itunes:episode>9</itunes:episode>

            
            <itunes:title>The IP Policy Institute’s Joshua Kresh and Emily Michiko Morris</itunes:title>
            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, interviews Joshua Kresh and Emily Michiko Morris from The IP Policy Institute at the University of Akron School of Law to disc...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, interviews Joshua Kresh and Emily Michiko Morris from The IP Policy Institute at the University of Akron School of Law to discuss the critical importance of protecting intellectual property for the biopharmaceutical innovation ecosystem and their recent research around evergreening and patent thickets.]]>
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            <pubDate>Mon, 08 Sep 2025 18:00:00 +0000</pubDate>
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            <title>Director of Access and Policy Research at Johnson &amp; Johnson, Ulrich Neumann, MBA, MSc, MA</title>
            <itunes:episode>6</itunes:episode>

            
            <itunes:title>Director of Access and Policy Research at Johnson &amp; Johnson, Ulrich Neumann, MBA, MSc, MA</itunes:title>
            <itunes:subtitle>Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, interviews Ulrich Neumann, MBA, MSc, MA, Director of Access and Policy Research at  Johnson &amp; Johnson, to discuss the mot...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, interviews Ulrich Neumann, MBA, MSc, MA, Director of Access and Policy Research at  Johnson & Johnson, to discuss the motivation behind the recent launch of the J&J Center for U.S. Healthcare Policy Research, the interconnectedness and importance of the various players within the biopharmaceutical R&D ecosystem, and the private capital that is required to develop new drugs.

Resources mentioned in this episode:
https://policyresearch.jnj.com
https://jnjinnovation.com/home
https://www.nature.com/articles/d41573-024-00131-2
https://www.ispor.org/docs/default-source/intl2024/j-j-access-policy-research---ispor-2024---pharma-r-d-ecosystem-investment137860-pdf.pdf?sfvrsn=d28181d4_0
https://www.tandfonline.com/doi/full/10.1080/13696998.2024.2405407]]>
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            <pubDate>Wed, 13 Aug 2025 18:30:00 +0000</pubDate>
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            <itunes:episode></itunes:episode>

            
            <itunes:title>Head of Patient Engagement and Patient-Centered Innovation, Raven, RA Capital&#039;s healthcare incubator, Gunnar Esiason, MBA, MPH</itunes:title>
            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, talks with Gunnar Esiason, Head of Patient Engagement and Patient-Centered Innovation at Raven, RA Capital&#039;s healthcare incuba...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, talks with Gunnar Esiason, Head of Patient Engagement and Patient-Centered Innovation at Raven, RA Capital's healthcare incubator, where they discuss the far-reaching impact of biopharmaceutical innovation, as well as the time, effort, and capital that goes into developing new treatments.]]>
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            <pubDate>Mon, 14 Jul 2025 17:30:00 +0000</pubDate>
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            <title>Vice Chair of Research and Associate Professor, University of Utah, Joey Mattingly, PharmD, MBA, PhD</title>
            <itunes:episode></itunes:episode>

            
            <itunes:title>Vice Chair of Research and Associate Professor, University of Utah, Joey Mattingly, PharmD, MBA, PhD</itunes:title>
            <itunes:subtitle>Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, interviews Joey Mattingly, PharmD, MBA, PhD, Vice Chair of Research and Associate Professor at the University of Utah, to...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics, interviews Joey Mattingly, PharmD, MBA, PhD, Vice Chair of Research and Associate Professor at the University of Utah, to learn about the history of the pharmaceutical supply chain and the origins of some of its components.]]>
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            <pubDate>Tue, 17 Jun 2025 18:00:00 +0000</pubDate>
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            <title>Chief Science Officer, National Pharmaceutical Council, Jon Campbell, PhD</title>
            <itunes:episode>5</itunes:episode>

            
            <itunes:title>Chief Science Officer, National Pharmaceutical Council, Jon Campbell, PhD</itunes:title>
            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics, interviews Jon Campbell, Chief Science Officer of the National Pharmaceutical Council, to discuss what makes biopharmaceutical...</itunes:subtitle>
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            <pubDate>Wed, 21 May 2025 18:00:00 +0000</pubDate>
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            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics interviews Elizabeth Franklin, PhD, MSW, Head of U.S. Public Affairs and Patient Advocacy, Oncology with Sanofi where they disc...</itunes:subtitle>
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            <pubDate>Wed, 23 Apr 2025 18:00:00 +0000</pubDate>
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            <title>Senior Policy Advisor at DLA Piper &amp; Non-Resident Fellow at the American Enterprise Institute, Kirsten Axelsen</title>
            <itunes:episode>3</itunes:episode>

            
            <itunes:title>Senior Policy Advisor at DLA Piper &amp; Non-Resident Fellow at the American Enterprise Institute, Kirsten Axelsen</itunes:title>
            <itunes:subtitle>Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics interviews Kirsten Axelsen, Senior Policy Advisor at DLA Piper &amp; Non-Resident Fellow at the American Enterprise Institute where...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics interviews Kirsten Axelsen, Senior Policy Advisor at DLA Piper & Non-Resident Fellow at the American Enterprise Institute where they discuss drug prices, their opportunity costs, and the effect today’s prices have on future drug developments.]]>
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            <pubDate>Wed, 26 Mar 2025 18:00:00 +0000</pubDate>
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            <title>Managing Director of Pharmagellan and Professor of the Practice at Tufts University, Frank S. David, MD, PhD</title>
            <itunes:episode>2</itunes:episode>

            
            <itunes:title>Managing Director of Pharmagellan and Professor of the Practice at Tufts University, Frank S. David, MD, PhD</itunes:title>
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                <![CDATA[Melanie Whittington, Head of the Leerink Center for Pharmacoeconomics interviews Frank S. David, MD, PhD, Managing Director of Pharmagellan and Professor of the Practice at Tufts University. The healthcare investing and development world and the pharmacoeconomics world have historically operated separately despite drug pricing being core to both worlds. In this episode, Mel and Frank contrast how models are used and built in their respective worlds of pharmacoeconomics and healthcare investing and development.]]>
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            <pubDate>Wed, 26 Feb 2025 19:00:00 +0000</pubDate>
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            <title>Author of the Cost Curve &amp; the Principal and Founder of Reid Strategic, Brian Reid</title>
            <itunes:episode>1</itunes:episode>

            
            <itunes:title>Author of the Cost Curve &amp; the Principal and Founder of Reid Strategic, Brian Reid</itunes:title>
            <itunes:subtitle>Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics interviews Brian Reid, Author of the Cost Curve &amp; the Principal and Founder of Reid Strategic. In this episode they discus...</itunes:subtitle>
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                <![CDATA[Melanie Whittington, PhD, Head of the Leerink Center for Pharmacoeconomics interviews Brian Reid, Author of the Cost Curve & the Principal and Founder of Reid Strategic. In this episode they discuss Brian's background in the health journalism space, Generalized Cost Effectiveness Analysis (GCEA), and how the industry can better communicate the impact of healthcare innovation.]]>
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            <pubDate>Wed, 29 Jan 2025 19:00:00 +0000</pubDate>
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            <title>Welcome to Perspectives by the Leerink Center for Pharmacoeconomics</title>
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            <itunes:title>Welcome to Perspectives by the Leerink Center for Pharmacoeconomics</itunes:title>
            <itunes:subtitle>In our signature podcast series, Dr. Mel Whittington, a health economist and Head of the Leerink Center for Pharmacoeconomics, talks with people from across the industry to hear their stories and t...</itunes:subtitle>
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                <![CDATA[In our signature podcast series, Dr. Mel Whittington, a health economist and Head of the Leerink Center for Pharmacoeconomics, talks with people from across the industry to hear their stories and to better understand the societal impact of healthcare innovations. If you’re interested in participating in future podcasts or would like to learn more about the Leerink Center for Pharmacoeconomics, please email cpe@medacorp.com. ]]>
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            <pubDate>Mon, 06 Jan 2025 10:00:00 +0000</pubDate>
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